Our Approach

Techulon’s approach is enabled by genomic techniques that have matured to the point of application toward neutralization of bacterial strains. Two key factors provide the right technology environment for development of an effective narrow-spectrum solution:
  1. Techulon has identified and developed an informatics workflow to rapidly identify within the bacterial genome, safe and targeted antibiotic agents.

  2. Targets have been synthesized based on PPNA technology yielding antisense agents targeted to specific S. aureus genes.  The sequences targeted exist in no other bacteria strain, and additionally do not exist in humans either, which suggests little opportunity for off target effects.  Techulon has synthesized these agents against over 70 targets to date and all compounds can be made with high purity agents and reproducibility.